客座研究员

    陈  涛 教授

  陈涛，医学博士，空军军医大学基础医学院人体解剖与组织胚胎学教研室主任、教授，军事医学创新中心研究员，博士生导师。西北工业大学、西北大学特聘研究员。

现任中国解剖学会神经解剖学分会副主任委员，青年工作委员会常务委员，中国生理学会疼痛转化研究专业委员会委员，SCI期刊《Mol Brain》《Mol Pain》《Front Mol Neurosci》副主编或编委。

主要从事慢性痛以及相关负性情绪和认知改变的中枢调控机制研究。至今，共发表SCI 收录论文近百篇，其中，以通讯作者和第一作者在 Science , Neuron,  Nature Communications（2）, Research, eLife，Neuropsychopharmachology , J Neurosci, Cereb cortex等神经科学和痛觉研究权威学术刊物发表论文30余篇。以项目负责人承担国家自然科学基金项目5项，加拿大国立健康研究院（CIHR）博士后科研基金1项，陕西省杰出青年基金等。

代表性研究成果

1. Ming-Ming Zhang, Tao Chen*. Empathic pain: underlying neural mechanism. The Neuroscientist, 2024 https://doi.org/10.1177/107385842412834

2. Jian Wang, Junxiang Gu, Fujuan Ma, Yi Wei, Pan Wang, Shanming Yang, Xianxia Yan, Yifan Xiao, Keke Xing, Anxin Lou, Liru Zheng, Tingting Cao, Dayu Zhu, Jinlian Li, Luoying Zhang, Yunqing Li, and Tao Chen*. Melatonin Induces Analgesic Effects through MT2 Receptor-Mediated Neuroimmune Modulation in the Mice Anterior Cingulate Cortex. Research, 2024 8 Oct,Vol 7, Article ID: 0493 DOI: 10.34133/research.0493

3. Wenyu Peng, Pan Wang, Chaoyang Tan, Han Zhao, Kun Chen, Huaxing Si, Yuchen Tian, Anxin Lou, Zhi Zhu, Yifang Yuan, Kaijie Wu*, Chao Chang*, Yuanming Wu*, Tao Chen*. High Frequency Terahertz Stimulation Alleviates Neuropathic Pain by Inhibiting the Pyramidal Neuron Activity in the Anterior Cingulate Cortex of mice. eLife, 2024. Sep 27:13:RP97444.

4. Chun-Kui Zhang, Pan Wang, Yuan-Yuan Ji, Jian-Shuai Zhao, Jun-Xiang Gu, Xian-Xia Yan, Hong-Wei Fan, Ming-Ming Zhang, Yu Qiao, Xiao-Die Liu, Bao-Juan Li, Ming-Hui Wang, Hai-Long Dong, Hao-Hong Li, Peng-Cheng Huang, Yun-Qing Li*, Wu-Gang Hou*, Jin-Lian Li*, Tao Chen*. Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain. Sci China Life Sci 2024 Jan;67(1):67-82. DOI: 10.1007/s11427-023-2406-3

5. Zhang Ming-Ming, Geng An-Qi, Chen Kun, Wang Jian, Wang Pan, Qiu Xin-Tong, Gu Jun-Xiang, Fan Hong-Wei, Zhu Da-Yu, Yang Shan-Ming, Chen Qi-Yu, Zhou Zhao-Xiang, Fan Bo-Yuan, Bai Yang, Xing Ke-Ke, Feng Jia-Ming, Wang Jun-Da, Chen Yan, Lu Ya-Cheng, Liang Ying, Cao Peng, Kaang Bong-Kiun, Zhuo Min*, Li Yun-Qing*, Chen Tao*. Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain. Neuron, 2022 Jun 15;110(12):1993-2008.e6.

6. Xu Wang, Keke Xing, Mengge He, Ting He, Xinkuan Xiang, Tao Chen, Luoying Zhang, Haohong Li. National Science Review. 2022 Oct 16;10(1):nwac222

7. Xu-Hui Li, Takanori Matsuura, Man Xue, Qi-Yu Chen, Ren-Hao Liu, Jing-Shan Lu, Wantong Shi, Kexin Fan, Zhaoxiang Zhou, Zhuang Miao, Jiale Yang, Sara Wei, Feng Wei, Tao Chen, Min Zhuo. Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation. Cell Reports. 2021 Jul 20;36(3):109411

8. Yin JB, Liang SH, Li F, Zhao WJ, Bai Y, Sun Y, Wu ZY, Ding T, Sun Y, Liu HX, Lu YC, Zhang T, Huang J, Chen T, Li H, Chen ZF, Cao J, Ren R, Peng YN, Yang J, Zang WD, Li X, Dong YL, Li YQ. dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors. J Clin Invest. 2020 Dec 1;130(12):6555-6570.

9. Li-Jun Zhou, Jiyun Peng, Ya-Nan Xu, Wei-Jie Zeng, Jun Zhang, Xiao Wei, Chun-Lin Mai, Zhen-Jia Lin, Yong Liu, Madhuvika Murugan, Ukpong B Eyo, Anthony D Umpierre, Wen-Jun Xin, Tao Chen, Mingtao Li, Hui Wang, Jason R Richardson, Zhi Tan, Xian-Guo Liu, Long-Jun Wu. Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. Cell Reports . 2019 Jun 25;27(13):3844-3859.e6. doi: 10.1016/j.celrep.2019.05.087.

10. Wang Jiejie, Lv Xinyou, Wu Yu, Xu Tao, Jiao Mingfei, Yang Risheng, Li Xia, Chen Ming, Yan Yinggang, Chen Changwan, Dong Weifan, Yang Wei, Zhuo Min, Chen Tao*, Luo Jianhong*, and Qiu Shuang*. Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons. Nature Communications 2018 Jun 11;9(1):2267.

11. Chen Tao, Taniguchi Wataru, Chen Qi-Yu, Tozaki-Saitoh Hidetoshi, Song Qian, Liu Ren-Hao, Koga Kohei, Matsuda Tsuyoshi, Kaito-Sugimura Yae, Wang Jian, Li Zhi-Hua, Lu Ya-Cheng, Inoue Kazuhide, Tsuda Makoto, Li Yun-Qing *, Nakatsuka Terumasa *, Zhuo Min *. Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex. Nature Communications 2018,9:1886-1903.

12. Song Qian, Zheng HongWei, Li XuHui, Huganir Richard, Kuner Thomas, Zhuo Min*, Chen Tao*. Selective Phosphorylation of AMPA Receptor Contributes to the Network of Long-Term Potentiation in the Anterior Cingulate Cortex. Journal of Neuroscience. 2017 Aug 30;37(35):8534-8548.

13. Zhang K, Li YJ, Guo Y, Zheng KY, Yang Q, Yang L, Wang XS, Song Q, Chen T, Zhuo M, Zhao MG. Elevated progranulin contributes to synaptic and learning deficit due to loss of fragile X mental retardation protein. Brain. 2017 Dec 1;140(12):3215-3232.

14. Koga, Kohei ，Descalzi, Giannina， Chen, Tao, Ko, Hyoung-Gon，Lu, Jinshan，Li, Shermaine，Son, Junehee，Kim, TaeHyun，Kwak, Chuljung，Huganir, Richard L，Zhao, Ming-Gao，Kaang, Bong-Kiun，Collingridge, Graham L，Zhuo, Min(*)，Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain. Neuron，2015，85（2）：377-389.

15. Koga, Kohei，Liu, Ming-Gang，Qiu, Shuang，Song, Qian，O'Den, Gerile，Chen, Tao，Zhuo, Min. Impaired presynaptic long-term potentiation in the anterior cingulate cortex of Fmr1 knock-out mice. Journal of Neuroscience，2015，35:2033-2043.

16. Chen Tao, Lu Jing-Shan，Song Qian，Liu Ming-Gang，Koga Kohei，Descalzi Giannina，Li Yun-Qing，Zhuo Min. Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome. Neuropsychopharmacology，2014，39（8）: 1955-1967.

17. Qiu, Shuang, Chen, Tao, Koga, Kohei，Guo, Yan-yan，Xu, Hui，Song, Qian，Wang, Jie-jie，Descalzi, Giannina，Kaang, Bong-Kiun，Luo, Jian-hong，Zhuo, Min，Zhao, Ming-gao，An increase in synaptic NMDA receptors in the insular cortex contributes to neuropathic pain. Science Signaling，2013，6(275):ra34-ra34.

18. Kang SJ, Liu MG, Chen T, Ko HG, Baek GC, Lee HR, Lee K, Collingridge GL, Kaang BK, Zhuo M. Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation. J Neurosci. 2012 Aug 15;32(33):11318-29.

19. Wang, Hansen，Xu, Hui, Wu, Long-Jun，Kim, Susan S，Chen, Tao, Koga, Kohei，Descalzi, Giannina，Gong, Bo，Vadakkan, Kunjumon I，Zhang, Xuehan，Kaang, Bong-Kiun，Zhuo, Min. Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain.，Science Translational Medicine，2011，3（65）：65ra3-65ra3.

20. Abumaria N, Yin B, Zhang L, Li XY, Chen T, Descalzi G, Zhao L, Ahn M, Luo L, Ran C, Zhuo M, Liu G. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J Neurosci. 2011 Oct 19;31(42):14871-81.

21. Li, Xiang-Yao^(#), Ko, Hyoung-Gon^(#), Chen, Tao^(#), Descalzi, Giannina，Koga, Kohei，Wang, Hansen，Kim, Susan S，Shang, Yuze，Kwak, Chuljung，Park, Soo-Won，Shim, Jaehoon，Lee, Kyungmin，Collingridge, Graham L，Kaang, Bong-Kiun，Zhuo, Min. Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science，2010，330(6009): 1400-1404.

22. Vecsey CG, Baillie GS, Jaganath D, Havekes R, Daniels A, Wimmer M, Huang T, Brown KM, Li XY, Descalzi G, Kim SS, Chen T, Shang YZ, Zhuo M, Houslay MD, Abel T. Sleep deprivation impairs cAMP signalling in the hippocampus. Nature. 2009 Oct 22;461(7267):1122-5.

23. Huo, Fu-Quan^(#)，Chen, Tao^(#)，Lv, Bo-Chang，Wang, Jing，Zhang, Ting，Qu, Chao-Ling，Li, Yun-Qing，Tang, Jing-Shi，Synaptic Connections between GABAergic Elements and Serotonergic Terminals or Projecting Neurons in the Ventrolateral Orbital Cortex，Cereb Cortex，2009，19（6）：1263-1272.